Harley and Syborg's mission to take out former Soviet spies continue, right after Harley lifts the jewelry off the hands of their previous target, dropping her into a flaming building, while they escape in a news helicopter.
Syborg's next target works at the zoo, and after crashing the helicopter as her form of "landing," Harley leads the way into the facility, but the target see's them coming, and decides to release all the animals... which doesn't go well for him. As Harley is delighted to play with everything from chimps to giraffes, the guy they're after looses his head after poking (kicking) the bears one too many times.
Harley and Syborg don't have to go far to find the rest of the targets, as the targets have come to them, looking to end the rivalry once and for all. A big brawl breaks out, there are animals, bazookas and bagel grenades... yes, bagel grenades. Have you realized Syborg is Jewish yet? Anyways, when there's one lady left, it turns out that both she and Syborg used to be lovers, but as soon as they embrace for a kiss, she pulls a blade, and Syborg speeds his scooter up, knocking her onto a rhino's horn. It was a bad break up.
Syborg wants to handle the final target on his list alone... turns out this guy is nothing but a used car salesman who sold him his dream car with a busted radiator. The car got stripped in New York while a young Syborg walked to the nearest gas station for help, and he's never forgiven the salesmen since. Once Harley learns that she would have inherited the car, since Syborg has no family, she breaks her promise to stay out of it and throws the salesman out of the window herself.
Both Harley and Syborg head back to Coney Island and watch the sunrise. Harley's glad she's made a new friend and tells Syborg he can call whenever. Harley then gets back to her penthouse to find an old friend waiting for her, and it seems like Poison Ivy has a lead on who wants Harley dead.