Welcome to Gothtopia, the safest city on earth, where crime barely happens and Luke Fox has even given up being
Luke eventually starts to realize something is wrong, mostly because he's losing periods of time and figures out he's been wondering around the city for a couple of days. Meanwhile, his old friend from the Zero Year issue is operating in the Gotham Underground, running a gang/drug ring, and uses Rat-Catcher, his next in command, to set a trap for his old friend Luke.
Luke finds out that there's been a toxin introduced into his, and everyone else in Gotham's system, but before he can finish a vaccine, he gets a call that his dad is threatening to kill himself, something many in Gothtopia who start to crack end up doing. Luke ends up stopping his father before he very publicly shoots himself in the head, and brings Lucius back to the base, where an antidote is administered. Batwing gives Lucius a couple more doses for the family (but doesn't count himself, and tries to play off the one less vaccine as already thinking ahead) and tells him to stay home until everything gets worked out.
Problem is, Luke's sister Tam never came home. So when he returns to the house, he finds this out, and eventually heads to her boyfriend's apartment with his dad. Inside, the boyfriend is found dead, and Tam is nowhere to be found. Why? Well, because Rat Catcher has decided to use Tam as the cheese in his trap.